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Environmental Illness

Topic Overview

What is an environmental illness?

An environmental illness can occur when you are exposed to toxins or substances in the environment that make you sick. These health hazards may be found where you live, work, or play.

Maybe you have headaches that only occur on weekends. Or maybe you began to feel sick and got a rash after moving into a newly built home. These symptoms can be caused by exposure to toxic chemicals. For example:

  • Those weekend headaches may be caused by a broken furnace leaking carbon monoxide.
  • Materials in new buildings may cause nausea and rashes. And the paper that makes up the outside layers of drywall promotes mold growth. Exposure to these molds may cause symptoms and could lead to asthma attacks.

What causes environmental illnesses?

Exposure to some types of chemicals can cause an environmental illness. The more of the chemical you are exposed to, the more likely you are to get ill. Examples include:

  • Chemicals in cigarettes are known to cause lung cancer.
  • Exposure to asbestos, an insulating material found in some older buildings, can cause tumors, lung cancer, and other diseases.
  • Wood-burning stoves and poorly vented gas ranges can cause breathing problems.
  • Unsafe drinking water from a rural well polluted with pesticides or other poisons from a nearby industrial plant could cause allergies, cancer, or other problems.
  • Certain chemicals in the workplace may cause sterility, mainly in men.
  • Lead poisoning can cause health problems in children. It can also cause high blood pressure, brain damage, and stomach and kidney problems in adults.

What are the symptoms?

Symptoms of an environmental illness may be like those you can get with other conditions, such as:

  • Headache.
  • Fever and chills.
  • Nausea.
  • A cough.
  • Muscle aches.
  • A rash.

But your symptoms will depend on the cause of the illness or disease.

If you think that exposure to toxic chemicals or other health hazards could be making you sick, talk to your doctor.

How are environmental illnesses diagnosed?

An environmental illness can be hard to diagnose. You and your doctor may not know what is causing your symptoms. Or you may mistake your symptoms for another problem. Exposure to toxic chemicals can cause a wide range of common medical problems or make them worse.

An exposure history, which is a set of questions about your home, workplace, habits, jobs, lifestyle, and hobbies, can help you find out what is making you sick. It may point to chemicals or other hazards that you've been exposed to recently or in the past.

Keep a journal of your symptoms, and discuss it with your doctor. It may help you find patterns in your symptoms. This can help you and your doctor find out what is causing your illness.

How are they treated?

Early treatment includes stopping or reducing your exposure to what is making you sick. These things might help:

  • Improve your air quality by getting rid of the source of pollution. Don't allow smoking in your house. If smokers live in or visit your home, ask them to smoke outside.
  • Increase the amount of fresh air coming into your home. Adjust gas stoves, or replace them with electric ones. Check to make sure that exhaust fans work. Installing carbon monoxide alarms in your home can also protect you and your family.
  • Stop the health effects of mold exposure. Keep a dry environment indoors to reduce exposure to mold. Mold should be removed from buildings by trained professionals.

Further treatment will depend on your symptoms and what is causing your illness.

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  Allergies: Avoiding Indoor Triggers

Toxic Chemicals in Our Environment

Indoor air pollution

Indoor air pollution can affect you at home, work, or even places you visit. It is a common source of respiratory diseases, including asthma, allergies, and lung cancer. It can be worse in winter, when windows are shut tight and less fresh air can circulate.

See tips for reducing indoor air pollution, such as not allowing anyone to smoke in your home.

Cigarette smoke

One of the most common and toxic indoor air pollutants is cigarette smoke. Experts believe about 90% of lung cancers are caused by cigarette smoke.1 Smoking, or even inhaling secondhand smoke, increases your risk of heart attack and stroke.

Tobacco smoke contains many chemicals, some of which are known to cause cancer. If you are a nonsmoker and household members or coworkers will not stop smoking around you, ask that they smoke only in well-ventilated or isolated areas. Never smoke around children or allow them to be exposed to cigarette smoke, especially if they have asthma or allergies.

Exposure to cigarette smoke causes wheezing, coughing, and extra mucus (phlegm) in many children. Secondhand smoke also can cause fluid to build up in the inner ear, which can cause ear infections. Lower respiratory infections, such as pneumonia and bronchitis, are also risks. Sometimes these types of infections become serious enough to require a hospital stay, especially when they develop in babies and young children.2

Babies who are exposed to secondhand smoke are at increased risk for sudden infant death syndrome (SIDS).3

Cigarette smoke may cause asthma in children.3 Also, children with asthma who are exposed to cigarette smoke have more attacks and more severe symptoms than other children with asthma.3

See information on the increased impact of environmental illnesses on children. For example, in recent years, the number of children with asthma has more than doubled, and environmental causes are suspected.

Woodstoves and gas ranges

Woodstoves that are not properly maintained and vented can give off tiny particles (particulates) and gases, including carbon monoxide, nitrogen, and hydrocarbons. Children in homes heated with woodstoves are at increased risk for respiratory problems. Gas ranges, particularly when they are not well-vented or when they are used as a source of heat, may produce nitrogen dioxide, which can cause respiratory problems. Consider changing to an electric stove.

If your gas stove has a persistent yellow flame, it may be improperly adjusted. Ask your gas company to adjust the burners so the flame tips are blue. If you're planning to buy a new gas range or stove, consider one that does not use a pilot light.

If you use a woodstove, make sure the stove doors fit tightly. Burn only aged or cured wood that is completely dry. Never burn pressure-treated wood because it is treated with chemicals.

Have chimneys, flues, and furnaces inspected each year.

For more information, see the topic Carbon Monoxide Poisoning.

Building materials

Exposure to building materials, products used for home improvement, and textiles can cause health problems. For example, particleboard, insulation, carpet adhesives, and other household products emit formaldehyde, which can cause nausea, respiratory problems, dry or inflamed skin, and eye irritation. Newly built homes and the confined spaces of mobile homes can be a particular problem. Using environmentally safe products—such as paint that contains a low level of or no volatile organic compounds (VOCs)—can reduce the chemical load on your body.

Sick building syndrome and building-related asthma

Experts coined the term "sick building syndrome" to describe acute symptoms that occur only during time spent in a particular building and that cannot be explained by any specific illness or cause. Symptoms include headache, dry cough, dry or itchy skin, dizziness, nausea, difficulty concentrating, fatigue, sensitivity to odors, and irritation of the eyes, nose, or throat. Typically the symptoms improve after you leave the building.

Poor ventilation that restricts fresh air flow inside can be a cause of sick building syndrome. Carpet, adhesives, upholstery, manufactured wood, pesticides, and cleaning fluids can give off volatile organic compounds (VOCs), including formaldehyde. High concentrations of VOCs can cause cancer. Unvented gas and kerosene space heaters, woodstoves, fireplaces, and gas stoves can produce carbon monoxide and nitrogen dioxide.

Outdoor sources of chemicals can also cause sick building syndrome. Pollutants from cars and trucks and exhaust from plumbing vents and building machinery can enter a building through vents.

Building-related asthma is the term used when symptoms of a diagnosed illness can be linked directly to airborne contaminants within a building. Symptoms include cough, chest tightness, and wheezing. Leaving the building may not immediately improve the symptoms.

Bacteria, molds, viruses, and other biological contaminants

Bacteria and molds can breed in stagnant water that builds up in humidifiers, drain pans, and ducts, or where water collects on carpet, ceiling tiles, and insulation. Humidifier fever is an illness caused by toxins from microorganisms that grow not only in large heating and cooling systems in buildings but also in home systems and humidifiers. Legionella pneumophila is an indoor bacterium that can cause Legionnaires' disease.

Some viruses can survive on household surfaces, such as counters or floors, or they can get spread through the air when an infected person sneezes or coughs. You can help control viruses by:

  • Cleaning household surfaces with a disinfectant.
  • Having adequate ventilation in your house.
  • Having anyone with a viral infection, such as a cold or the flu, cough or sneeze into the bend of the elbow or into a tissue.

Pet dander, pollen, dust mites, molds, and rat and mouse urine are allergens that can cause asthma, allergic rhinitis, and other lung problems. Symptoms of illness caused by biological contaminants include sneezing, watery eyes, shortness of breath, lethargy, dizziness, and digestive problems.

Exposure early in life to indoor allergens such as molds may increase the risk of allergies or asthma.4 Allergies to molds can also make asthma attacks worse or cause other breathing problems.

Keep your home clean and as free from dust as possible to help reduce allergens. There are many ways to control dust and dust mites in your home, such as washing bedding in hot water to kill dust mites and eliminating furnishings, such as drapes, that collect dust. Also, there are many steps you can take to control animal dander and other pet allergens.

Exhaust fans that vent to the outdoors and are installed in kitchens and bathrooms can help get rid of moisture that allows microorganisms, including molds, to grow. When modern building materials get wet, they provide an ideal place for the growth of molds, which can make asthma attacks worse and may cause other respiratory symptoms. Ventilating attic and crawl spaces and keeping humidity levels below 50% can help prevent moisture buildup in building materials. There are other ways to control indoor molds, such as preventing leakage, removing wet materials, storing fireplace wood outside the home, and using a dehumidifier during humid weather.

Keep humidifiers clean and refill them daily with fresh water. Frequently clean evaporation trays in air conditioners, dehumidifiers, and refrigerators. Water-damaged carpets and building materials can also have molds and bacteria in them. It is difficult to get rid of bacteria or molds. So, if possible, replace or remove water-damaged items from your home.

You can also:

  • Remove carpets and replace them with hardwood or tile floor.
  • Have sofas with covers that can be removed and washed.
  • Use blinds instead of drapes, because they collect less dust.
  • Have air filters in some rooms, especially in the bedroom.

For more information, see:

Click here to view an Actionset.Allergies: Avoiding Indoor Triggers.
Household products

Many of the products you use to clean your home or use for hobbies and home improvement projects contain potentially hazardous chemicals. Some can be toxic and in sufficient doses can cause eye and respiratory problems, headaches, dizziness, visual problems, and memory impairment. One of the most important ways you can protect yourself is by following the instructions on the label. When you use cleaning or other products, be sure to open windows or use an exhaust fan to provide good ventilation. Never mix household chemicals, such as chlorine bleach and ammonia. Some mixtures can create toxic fumes that can be fatal.

It's better to use environmentally safe products. Vinegar, lemon juice, boric acid, or baking soda can be used instead of store-bought household cleaners. And they are less damaging to you and to the environment.

Be especially careful with products containing methylene chloride, including paint strippers, adhesive removers, and aerosol spray paints. If you use products that contain this chemical, make sure you have adequate ventilation or use them outdoors, if possible. Also, wear gloves to avoid skin contact. But whenever you can, use environmentally safe products instead.

Avoid exposure to benzene, which can cause cancer. Benzene is found in tobacco smoke, stored fuels, paint supplies, and vehicle exhaust. Also, try to limit your exposure to newly dry-cleaned clothing or furnishings. Dry-cleaned goods may emit perchloroethylene (also known as tetrachloroethylene) and trichloroethylene. These chemicals may cause skin rashes, headaches, and dizziness5. If your clothes emit a strong odor when you pick them up from the cleaners, they may not have been dried properly and can release more of this chemical. After removing the protective plastic from the clothes, hang them outside, if possible. Consider finding a dry cleaner that uses less toxic chemicals.

Asbestos

Asbestos is an insulating material commonly used from the 1950s to 1970s for soundproofing and to cover floors and ceilings, water pipes, and heating ducts. When it becomes crumbly or frayed, asbestos fibers can be released into the air. Breathing asbestos fibers may cause lung cancer, asbestosis (scarring of the lung tissue), or mesothelioma.

Radon

Radon is a colorless, odorless radioactive gas that can enter your home through cracks in concrete walls and floors and through floor drains. The most common source of radon is uranium that normally exists in the soil or rock on which homes are built. Problems show up when the concentration of radon builds up in a home or building. Both old or new homes can have problems with radon even if they don't have a basement.

Exposure to radon gas is the second leading cause of lung cancer. (Tobacco smoke is the leading cause.) The risk of radon-associated lung cancer is much higher for smokers than nonsmokers.6

You cannot smell or see radon. But it's easy to test for it with a do-it-yourself kit available in hardware stores or through the U.S. Environmental Protection Agency (EPA). For more information, see the topic Radon.

Treatment for indoor air pollution

How you react to indoor air pollutants depends on your age, health, and how sensitive you are to certain chemicals or biological pollutants, such as bacteria or molds. Treatment can be as simple as removing and limiting your exposure to toxic chemicals in your home. In some cases, serious illnesses—such as cancer, heart disease, and respiratory disease—can develop after long-term and repeated exposures. With such long-term exposures, treatment may be extensive, depending on the type of illness.

Outdoor air pollution

Polluted air comes from many sources, such as factories, cars, buses, trucks, and power plants. And there are other sources that you may not think of, such as dry cleaners, wildfires, and dust. Dirty air is a threat to your health. And it also damages crops, trees, water, and animals.

There are at least six major components of air pollution:

  • Ozone. Ozone is a gas that exists at ground level as well as miles above the earth. It's made by a chemical reaction between nitrogen oxides and volatile organic compounds (VOCs) in the presence of heat and sunlight. "Good" ozone occurs naturally about 10 to 30 miles above the earth's surface. There, in the stratosphere, it forms a layer that protects the earth's surface from the sun's harmful rays. At ground level, "bad" ozone (smog) exists. Exhaust from vehicles, industrial emissions, gasoline vapors, and chemical solvents are major sources of nitrogen oxides and VOCs. Add sunlight and hot weather to the mix, and harmful concentrations of ozone may develop. Because of the heat factor, ground-level ozone is a summertime air pollutant that can be dangerous, especially for people with respiratory illnesses. Problems include:
    • Irritation of the lungs that causes inflammation much like a sunburn.
    • Coughing, wheezing, and pain when taking a deep breath, and breathing problems while exercising.
    • Permanent lung damage from repeated exposure.
    • Aggravated asthma, increased susceptibility to pneumonia and bronchitis, and reduced lung capacity.
  • Particulates. Particulates include dust, dirt, soot, smoke, and liquid droplets found in the air. They come from many sources, such as vehicles, factories, construction sites, unpaved roads, and burning wood. Other particulates are formed when gases from burning fuels react with water vapor and sunlight. This can result from the combustion of fuels in motor vehicles and from industrial and power plants. Particulates in the air you breathe can cause:
    • Aggravated asthma.
    • Chronic bronchitis.
    • Coughing and difficult or painful breathing.
    • Reduced lung function.
    • Eye, nose, and throat irritation.
  • Carbon monoxide. In cities with lots of traffic, most of the carbon monoxide put into the air comes from vehicle exhaust. It also comes from manufacturing processes, wood burning, and forest fires. Indoor sources include cigarettes and space heaters. Carbon monoxide reduces the body's ability to deliver oxygen to tissues and organs, such as the heart and brain. It is especially dangerous for people who have heart problems. Carbon monoxide can be fatal to those exposed to extremely high levels. Every year carbon monoxide poisoning is a leading cause of deaths from toxic chemicals. People with carbon monoxide poisoning may have:
  • Nitrogen dioxide. When mixed with other particles in the air, nitrogen dioxide can often be seen as a reddish brown layer over many urban areas. Sources are fuels burned by vehicles, electric utilities, and industrial plants. Nitrogen dioxide is one of the nitrogen oxides, a group of highly reactive gases that contain various amounts of nitrogen and oxygen. Nitrogen oxides cause many problems, including:
    • Respiratory problems associated with ground-level ozone.
    • Acid rain, which is made when nitrogen oxides and sulfur dioxide react with other substances in the air and form acids. The acids then fall to earth as rain, snow, dry particles, or fog.
    • Toxic chemicals. Nitrogen oxides mix with common organic chemicals and even ozone to create toxic chemicals that can cause biological mutations.
    • Visibility impairment. Nitrogen dioxide and nitrate particles block light transmission and reduce visibility in urban areas.
  • Sulfur dioxide. These gases are formed when fuels containing sulfur are burned. Examples are when coal and oil burn, when gasoline is extracted from oil, or when metals are extracted from ore. Sulfur dioxide is put into the air when fossil fuel is burned, such as by coal-fired power plants. Other sources are industries that create products from metallic ore, coal, and crude oil or those that burn coal or oil, such as petroleum refineries or metal processing facilities. Sulfur dioxide causes:
    • Health problems for people with asthma and heart conditions.
    • Acid rain.
    • Damage to forests and crops.
    • Damage to fish in streams and lakes.
  • Lead. Leaded gasoline used to be the main source of lead in the air. But because leaded fuels have been phased out, the main sources of lead emissions are metals-processing facilities, especially lead smelters. Lead may cause serious health problems, including:
    • Damage to kidneys, liver, brain, nerves, and other organs. Lead may also cause osteoporosis and reproductive problems. Excessive exposure can cause seizures, intellectual disability, behavioral disorders, memory problems, and mood changes. Low levels of lead cause brain and nerve damage in young children and fetuses, which can lead to learning problems and low IQ.
    • High blood pressure and increases in heart disease.
    • Anemia.

For more information, see the topics Carbon Monoxide Poisoning and Lead Poisoning.

Pesticides

Exposure to pesticides may come from residual agricultural pesticides in foods; from household or workplace products used to control rodents, insects, and termites; and from disinfectants and fungicides. The most likely ways you are exposed are small quantities of pesticides in the foods you eat and by direct contact with surfaces (such as plants, soils, or structures) where pesticides have been used.

If not used properly, both workplace and household pesticides can be dangerous. Exposure to high levels of some pesticides can cause headaches, dizziness, muscle twitching, nausea, weakness, and tingling sensations. Some experts believe that some pesticides may cause cancer or damage to the liver and central nervous system.7, 8 Pesticide exposure during pregnancy has been associated with miscarriage, fetal death, and early childhood cancers such as acute lymphoblastic leukemia (ALL). Indoor use of pesticides increases children's risk of brain tumors, ALL, and birth defects. Children can be poisoned by stored pesticides, so these should always be kept out of reach. For agricultural workers, exposure to pesticides has been linked with an increased risk of non-Hodgkin's lymphoma.9

See tips for reducing pesticide exposure in your home, such as reducing your use of lawn and garden pesticides and limiting your exposure to moth repellents.

Mercury in fish

For most people, the level of mercury absorbed by eating fish and shellfish is not a health concern. But in a fetus or young child, this can damage the brain and nerves (nervous system). Because of the mercury found in fish, the U.S. Food and Drug Administration (FDA) and the U.S. Environmental Protection Agency (EPA) advise women who may become pregnant, pregnant women, nursing mothers, and young children to avoid eating fish high in mercury and to eat limited amounts of fish and shellfish that are lower in mercury.10 For more information, see the topic Avoiding Mercury in Fish.

Chemicals from plastics and other products

Some people are concerned about bisphenol A (BPA). This is a chemical found in some types of plastic (polycarbonate) bottles. A study has shown that people with high levels of BPA in their urine have a greater risk for heart disease.11 And a group of experts concluded that bisphenol A may have some effect on the behavior, brain, and prostate gland of a developing baby (fetus) or young child.12, 13 If you are concerned about BPA, don't use bottles marked with the number 7 or the letters "PC" near the recycle symbol. You can use glass or BPA-free plastic bottles instead.

In the past, a group of substances called polychlorinated biphenyls (PCBs) were used in electrical equipment, plastics, and dyes. Although they are no longer made in the U.S., they remain in the environment. Exposure to PCBs has been linked to health problems, especially mental functions such as memory and attention in children.14 The U.S. Environmental Protection Agency (EPA) provides information about PCBs at http://www.epa.gov/epawaste/hazard/tsd/pcbs/index.htm.

Chemicals called phthalates may cause problems with the reproductive organs of infants and young children, especially boys. Phthalates can be found in some plastic items (such as some medical devices) and in products such as powders, lotions, and shampoos.15, 16

Who to Call

If you believe you have an environmental illness, first consider your symptoms. If your symptoms are severe (for example, you are having trouble breathing), you have ingested household chemicals, or you fear you may have a carbon monoxide leak in your home, call your Poison Control Center immediately. Otherwise, contact:

You may find it helpful to create a written exposure history to take to your doctor, to help identify the cause of your illness.

Other Places To Get Help

Organizations

Agency for Toxic Substances and Disease Registry (ATSDR)
1825 Century Boulevard
Atlanta, GA  30345
TDD: 1-800-232-4636
Email: cdcinfo@cdc.gov
Web Address: www.atsdr.cdc.gov
 

The Agency for Toxic Substances and Disease Registry (ATSDR), an agency of the U.S. Department of Health and Human Services, works to serve the public by using the best science, taking responsive public health actions, and providing trusted health information to prevent harmful exposures and disease related to toxic substances.


Centers for Disease Control and Prevention: National Center for Environmental Health
1600 Clifton Road
Atlanta, GA  30333
Phone: (770) 488-7100 for CDC Emergency Response
1-800-CDC-INFO (1-800-232-4636)
Email: cdcinfo@cdc.gov
Web Address: www.cdc.gov/nceh

National Institute of Environmental Health Sciences
111 T.W. Alexander Drive
P.O. Box 12233
Research Triangle Park, NC  27709
Phone: (919) 541-3345
Fax: (919) 541-4395
Email: webcenter@niehs.nih.gov
Web Address: www.niehs.nih.gov
 

The National Institute of Environmental Health Sciences (NIEHS) uses environmental health sciences to understand the causes of disease and to improve human health. NIEHS research focuses on complex human disease and calls for scientists to investigate a broad spectrum of disease factors including environmental agents, genetics, age, diet, and activity levels.


National Library of Medicine: ToxTown
8600 Rockville Pike
Bethesda, MD  20894
Phone: 1-888-FIND-NLM (1-888-346-3656)
Email: tehip@teh.nlm.nih.gov
Web Address: http://toxtown.nlm.nih.gov
 

The ToxTown website gives you information about toxic chemicals and environmental health risks that you might encounter in everyday life. It provides facts on everyday places where toxic chemicals may be found, and it gives information about how the environment can affect health. ToxTown includes common environmental hazards in towns, cities, farms, and U.S.-Mexico border communities. The site is interactive and very user-friendly. You click on simple graphics to be directed to specific information that you are interested in learning about.


National Pesticide Information Center
Oregon State University
333 Weniger Hall
Corvallis, OR  97331-6502
Phone: 1-800-858-7378
Email: npic@ace.orst.edu
Web Address: www.npic.orst.edu
 

The National Pesticide Information Center (NPIC) is a cooperative effort between Oregon State University and the U.S. Environmental Protection Agency. The NPIC has fact sheets about pesticide safety issues relating to home and garden use, food, water, and pets. They also have detailed information about pesticide manufacturers, chemicals found in products, pesticide labels, and more.


U.S. Environmental Protection Agency (EPA)
Ariel Rios Building
1200 Pennsylvania Avenue NW
Washington, DC  20460
Phone: (202) 272-0167
Email: library-hq@epa.gov
Web Address: www.epa.gov
 

The EPA's mission is to protect human health and safeguard the natural environment—air, water, and land—upon which life depends. It provides educational tools about environmental issues affecting health including pesticides, radon, water quality, mold, asbestos, and hazardous waste. The EPA website also provides contact information for hotlines and clearinghouses, and it contains a special section (www.epa.gov/epawaste/education/teens) with resources and games for teenagers.


References

Citations

  1. Ettinger DS (2008). Lung cancer and other pulmonary neoplasms. In L Goldman, D Ausiello, eds., Cecil Medicine, 23rd ed., pp. 1456–1465. Philadelphia: Saunders Elsevier.
  2. U.S. Environmental Protection Agency (2011). Smoke-free homes. Available online: http://www.epa.gov/smokefree/index.html.
  3. U.S. Environmental Protection Agency (2010). Health effects of exposure to secondhand smoke. Available online: http://www.epa.gov/smokefree/healtheffects.html.
  4. Iossifova YY, et al. (2009). Mold exposure during infancy as a predictor of potential asthma development. Annals of Allergy, Asthma, and Immunology, 102(2): 131–137.
  5. Agency for Toxic Substances and Disease Registry (2011). Toxic substances portal—Trichloroethylene (TCE): Public Health Statement for Trichloroethylene. Available online: http://www.atsdr.cdc.gov/phs/phs.asp?id=171&tid=30.
  6. U.S. Environmental Protection Agency (2012). A Citizen's Guide to Radon: The Guide to Protecting Yourself and Your Family From Radon. Available online:http://www.epa.gov/radon/pubs/citguide.html.
  7. Arcury TA, Quandt SA (2003). Pesticides at work and at home: Exposure of migrant farmworkers. Lancet, 362(9400): 2021.
  8. Baldi I, et al. (2011). Neurobehavioral effects of long-term exposure to pesticides: Results from the 4-year follow-up of the PHYTONER Study. Occupational and Environmental Medicine, 68(2): 108–115.
  9. Fritschi L, et al. (2005). Occupational exposure to pesticides and risk of non-Hodgkin’s lymphoma. American Journal of Epidemiology, 162(9): 849–857.
  10. U.S. Food and Drug Administration (2004). What you need to know about mercury in fish and shellfish: 2004 EPA and FDA advice for women who might become pregnant, women who are pregnant, nursing mothers, young children. Available online: http://water.epa.gov/scitech/swguidance/fishshellfish/outreach/advice_index.cfm.
  11. Melzer D, et al. (2010). Association of urinary bisphenol A concentration with heart disease: Evidence from NHANES 2003/06. Public Library of Science ONE, 5(1): e8673. Also available online: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2800195/?tool=pubmed.
  12. National Toxicology Program, Center for the Evaluation of Risks to Human Reproduction (2008). NPT-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A (NIH Publication No. 08-5994). Available online: http://cerhr.niehs.nih.gov/evals/bisphenol/bisphenol.pdf.
  13. Braun JM, et al. (2011). Impact of early-life bisphenol A exposure on behavior and executive function in children. Pediatrics, 128(5): 873–882.
  14. Chen A, et al. (2011). Developmental neurotoxicants in e-waste: An emerging health concern. Environmental Health Perspectives, 119(4): 431–438.
  15. National Toxicology Program, Center for the Evaluation of Risks to Human Reproduction (2006). NPT-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP) (NIH Publication No. 06-4476). Available online: http://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/DEHP-Monograph.pdf.
  16. Sathyanarayana S, et al. (2008). Baby care products: Possible sources of infant phthalate exposure. Pediatrics, 121(2): e260–e268.

Other Works Consulted

  • Crinnion WJ (2006). Environmental medicine. In JE Pizzorno Jr, MT Murray, eds., Textbook of Natural Medicine, 3rd ed., pp. 339–353. Edinburgh: Churchill Livingstone.
  • Hu H (2012). Heavy metal poisoning. In DL Longo et al., eds., Harrison's Principles of Internal Medicine, 18th ed., CD chapter e49. New York: McGraw-Hill Medical.
  • Ruder AM (2006). Potential health effects of occupational chlorinated solvent exposure. Annals of the New York Academy of Sciences, 1076: 207–227.
  • Swan SH, et al. (2005). Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environmental Health Perspectives, 113(8): 1056–1061.
  • Veraldi A, et al. (2006). Immunotoxic effects of chemicals: A matrix for occupational and environmental epidemiological studies. American Journal of Industrial Medicine, 49(12): 1046–1055.
  • Balmes JR, Speizer FE (2012). Occupational and environmental lung disease. In DL Longo et al., eds., Harrison's Principles of Internal Medicine, 18th ed., vol. 2, pp. 2121–2129. New York: McGraw-Hill Medical.
  • Centers for Disease Control and Prevention (2009). Fourth National Report on Human Exposure to Environmental Chemicals 2009: Executive Summary. Available online: http://www.cdc.gov/exposurereport.
  • U.S. Centers for Disease Control and Prevention (CDC) (2013). Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2013. Available online: http://www.cdc.gov/exposurereport.
  • U.S. Department of Health and Human Services Office on Smoking and Health (2006). The health consequences of involuntary exposure to tobacco smoke: A report of the Surgeon General. Available online: http://www.surgeongeneral.gov/library/secondhandsmoke.
  • Yu D (2008). Taking an Exposure History (ATSDR Course WB 1109). Atlanta: U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease Registry. Available online: http://www.atsdr.cdc.gov/csem/csem.asp?csem=17&po=0.

Credits

By Healthwise Staff
Primary Medical Reviewer Sarah Marshall, MD - Family Medicine
Specialist Medical Reviewer Peter Rabinowitz, MD, MPH - Occupational and Environmental Medicine
Last Revised August 7, 2012

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