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Rett's disorder, also called Rett's syndrome, is a brain disorder
characterized by normal early development (until sometime between 5 months and
4 years) that is followed by a loss of physical and mental growth. Rett's is
caused by gene mutation and usually only affects girls; most cases are not
passed from one generation to the next, but occur randomly.
Often the first noticeable sign of Rett's disorder is slowed head
growth. Loss of hand coordination and movement follows, replaced by repetitive
(stereotypical) hand wringing. Language development and social skills suffer
around 2 to 3 years of age. Eventually, physical problems progress so that the
child walks with difficulty—often stiffly with jerking. In addition, breathing
may become labored and produce a sighing sound. These problems can cause severe
disability and sometimes death.
Current as of:
November 20, 2015
John Pope, MD - Pediatrics & Fred Volkmar, MD - Child and Adolescent Psychiatry
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