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Melnick Needles Syndrome

National Organization for Rare Disorders, Inc.

Important
It is possible that the main title of the report Melnick Needles Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • MNS
  • Melnick-Needles osteodysplasty
  • osteodysplasty of Melnick and Needles

Disorder Subdivisions

  • None

General Discussion

Melnick-Needles syndrome (MNS) is a genetic disorder of bone characterized by skeletal abnormalities and a specific facial appearance. The skeletal abnormalities include bowing of long bones, s-curved leg bones, ribbon-like ribs and a hardening of the skull base. The typical facial features include prominent, protruding eyes, full cheeks, an extremely small lower jaw and a hairy forehead. The condition may affect many bones of the body causing deformity and in some cases short stature. MNS is thought to be inherited as an X-linked dominant genetic disorder.

Resources

Melnick-Needles Syndrome Support Group
4, Kivner Lane
Bexhill-On-Sea
East Sussex, TN40 2ST
United Kingdom
Tel: 01424217790
Email: gill@melnickneedlesyndrome.com
Internet: http://www.melnickneedlesyndrome.com

Genetic and Rare Diseases (GARD) Information Center
PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311
TDD: (888)205-3223
Internet: http://rarediseases.info.nih.gov/GARD/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  7/17/2012
Copyright  1989, 1996, 2004, 2008, 2012 National Organization for Rare Disorders, Inc.

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