Yellow Nail syndrome

National Organization for Rare Disorders, Inc.

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It is possible that the main title of the report Yellow Nail syndrome is not the name you expected.

Disorder Subdivisions

  • None

General Discussion

Yellow nail syndrome is an extremely rare disorder characterized by malformations affecting the fingernails and toenails, abnormalities affecting the lungs and the airways (respiratory tract), and swelling or puffiness in different parts of the body because of the accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin (lymphedema). Yellow nail syndrome usually affects older adults. The exact cause of yellow nail syndrome is not known. Occasionally, yellow nail syndrome has been reported to run in families suggesting that genetic factors may play a role in the development of the disorder in these cases.

Supporting Organizations

American Lung Association

55 W. Wacker Drive
Suite 1150
Chicago, IL 60601
Tel: 1-800-548-8252

Genetic and Rare Diseases (GARD) Information Center

PO Box 8126
Gaithersburg, MD 20898-8126
Tel: (301)251-4925
Fax: (301)251-4911
Tel: (888)205-2311

Lymphatic Education & Research Network

261 Madison Avenue
9th Floor
New York, NY 10016
Tel: 516-625-9675
Fax: 516-625-9410

Lymphovenous Canada

8 Silver Ave
Ontario, M6R 1X8
Tel: 4165332428

NIH/National Heart, Lung and Blood Institute

P.O. Box 30105
Bethesda, MD 20892-0105
Tel: (301)592-8573
Fax: (301)251-1223

National Lymphedema Network, Inc.

225 Bush Street
Suite 357
San Francisco, CA 94104
Tel: (415)908-3681
Fax: (415)908-3813
Tel: (800)541-3259

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

Last Updated:  5/15/2015
Copyright  2015 National Organization for Rare Disorders, Inc.