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These drugs kill Borrelia burgdorferi bacteria, which cause
Antibiotics are used to cure early
Lyme disease and to greatly reduce the risk of future complications.
Antibiotics may also be used in the later
stages of Lyme disease, when additional symptoms
involving the skin, joints, nervous system, or heart may develop.
The type of antibiotic prescribed depends on your age, symptoms, any antibiotic allergies you may have, and
the stage of Lyme disease. These medicines may be taken orally, as an injection, or
through a vein (intravenous, or IV). The length of antibiotic
treatment varies according to how bad the disease and your symptoms are, but
treatment generally lasts less than 4 weeks.
Early treatment with antibiotics can cure the Lyme disease infection and help
prevent future problems with arthritis, the heart, or the nervous system.1 But
symptoms may not go away right away. Some symptoms may last for several weeks
after treatment. This does not mean that the antibiotics were not successful,
nor does it mean that you need additional antibiotic treatment.
Antibiotic treatment for early symptoms of
chronic Lyme arthritis is usually very effective.
Joints that have been badly damaged by Lyme arthritis may take a long time to
get better after the infection has been cured, or they may not respond to
treatment at all. A small percentage of people in the United States continue to have
symptoms of chronic Lyme arthritis after treatment with antibiotics.2
Heart symptoms often begin to go away before
antibiotics are given. If not, they usually respond to antibiotic therapy
within days. Mild heart symptoms that may occur with early Lyme disease usually
improve after treatment with oral amoxicillin or doxycycline for 21 to 30
inflammation of the membrane surrounding the brain and
spinal cord (Lyme
meningitis) begin to improve by the second day of
therapy and usually disappear after 7 to 10 days.
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Call 911 or other emergency services right away if you have:
Call your doctor if you:
Common side effects of these medicines include:
Some people treated for early Lyme disease have headaches, muscle and joint pain, and tiredness that may continue for
a while after treatment. These symptoms usually go away on
their own within 6 months and do not require more treatment.
study suggests that people who take erythromycin along with certain common
medicines may raise their risk of sudden cardiac death.3 The study showed that the risk of dying from a heart problem is
greater when erythromycin is taken with some medicines—such as certain calcium channel blockers, certain antifungal
medicines, and some antidepressants—than when these medicines are not taken
See Drug Reference for a full list of side effects.
(Drug Reference is not available in all systems.)
should be taken with plenty of fluids and not while you are lying down or right
Doxycycline is the drug of choice for treating early Lyme
disease in people ages 8 and older. But it should not be given to pregnant
women or to people who are allergic to tetracycline.
If you get
intravenous (IV) antibiotics, you may have weekly
blood tests to check your white blood cell count. The IV antibiotic treatment
may lead to low levels of white blood cells (called leukopenia) that can make
it hard for you to fight infection.
With the exception of pregnant
women and people with severe arthritis or heart problems, most people who have
been exposed to ticks but do not have symptoms are not given antibiotics. Even
in parts of the country where Lyme disease is known to occur often, the risk of
getting Lyme disease is too small to warrant treatment before symptoms
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
Complete the new medication information form (PDF)new medication information form (PDF)(What is a PDF document?) to help you understand this medication.
Sharma SK, Kadhiravan T (2009). Lyme disease. In RE Rakel, ET Bope, eds., Conn's Current Therapy 2009, pp. 136–139. Philadelphia: Elsevier Saunders.
Steere AC (2010). Borrelia burgdorferi (Lyme Disease, Lyme Borreliosis). In GL Mandell et al., eds., Principles and Practices of Infectious Diseases, 7th ed., chap. 239, pp. 3071–3081. Philadelphia: Elsevier Churchill Livingstone.
Ray WA, et al. (2004). Oral erythromycin and the risk
of sudden death from cardiac causes. New England Journal of Medicine, 351(11): 1089–1096.
Current as of:
June 4, 2014
E. Gregory Thompson, MD - Internal Medicine & Christine Hahn, MD - Epidemiology
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